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Reported by Annette Kreuger, Industrial Info Resources (Sugar Land, Texas)--Despite a host of headaches, including steep patent losses and an industry in continual reorganization, Pfizer Incorporated (NYSE:PFE) (New York, New York) has managed to remain one of the world's largest drug companies. With revenues of $51.6 billion in 2013, the company is now intent on spending at least $100 billion to snatch up AstraZeneca plc (NYSE:AZN) (London, England).

Pfizer first came calling on the British-Swiss drug maker in January of this year, offering roughly $77 per share of AstraZeneca's stock, a premium of 30% that translated to a total topping $98 billion. Soundly rebuffed, Pfizer came back with a $100 billion deal, which would be the second-largest pharmaceutical buy, topped only by the company's $112 billion purchase of Warner Lambert in 2000.

See below for chart detailing all North American Astra Zeneca and Pfizer facilities.

AstraZeneca would boost Pfizer's pipeline of lucrative cancer drugs and create significant cost and tax savings. Under British takeover rules, Pfizer has until May 26 to announce a firm intention to make an offer or walk away from what would be the largest takeover of a British company by a foreign interest.

Click here to gain instant access to the all-new 2014 North American Pharmaceutical-Biotech Outlook.

If the deal goes as planned, Pfizer would be one of the biggest U.S. companies to decamp for a foreign country. The new company would incorporate in Britain but be headquartered in New York, New York, resulting in tax benefits to Pfizer that could top $1 billion annually.

Pfizer plans follow in the footsteps of a growing number of U.S. drug makers, choosing to establish legal homes in tax-friendly countries such as Britain and Ireland. Coined "inversions," these deals require companies to transfer at least 20% of their shares to foreign ownership in exchange for huge tax savings.

Following its move from Parsippany, New Jersey, to Dublin, Ireland, in 2013, Actavis plc (NYSE:ACT) announced a $25 billion merger with Forest Laboratories Incorporated (NYSE:FRX) in February of this year. The new company will be based in Ireland, where the corporate tax rate is 12.5%--much lower than the combined U.S. federal and state corporate tax rate of 40% or more in New York and New Jersey. Although "based" in Dublin, Actavis maintains its administrative headquarters in Parsippany.

North American Astra Zeneca and Pfizer Operational Manufacturing and Research Sites
Plant ID Operator Plant Name
1033924 AstraZeneca R&D Boston Waltham Pre-Clinical & Toxicology R&D
1031837 AstraZeneca SA de CV Naucalpan Tablets, Injectables & Oral Liquids
1045843 AstraZeneca US Wilmington Nexium Capsules, Injectables & Crestor Tablets
1035664 AstraZeneca US Newark Tablets, Injectables & Oral Liquids
1522707 AstraZeneca US Westborough Sterile Injectables
1036202 IPR Pharmaceuticals AstraZeneca Canovanas Crestor, Casodex & other Pharmaceuticals
1053669 MedImmune LLC (Astra Zeneca) Gaithersburg Biopharmaceutical R&D
1029893 MedImmune LLC (Astra Zeneca) Frederick Monoclonal Antibodies & Viral Vaccines CMO
1068406 MedImmune LLC (Astra Zeneca) Santa Clara R&D Pre-Clinical, Phase 1&2 Proteins & Vaccines
1068428 MedImmune LLC (Astra Zeneca) Mountain View Clinical Scale Vaccines and R&D
3092451 Pearl Therapeutics, Inc. (Astra Zeneca) Raleigh Metered Dose Inhaler (MDI) Products
3006845 Alacer Corporation (Pfizer) Carlisle Emergen-C Dietary Supplements Powders & Liquids
1034329 Meridian Medical Technologies
(Pfizer)
Saint Louis Auto-Injectors Diagnostics
1076785 Neusentis (Pfizer) Durham Small Molecule Drugs
1064177 Pfizer Canada Ottawa Cancer, Allergy and Asthma Vaccines R&D
1060505 Pfizer Global Research and Development New Haven Clinical Research Unit
1061469 Pfizer Incorporated Vega Baja Tablets & Capsules
1064844 Pfizer Incorporated Cambridge Global Research & Development Center
1058738 Pfizer Incorporated San Diego R&D Cancer & HIV Therapy Biologics & Vaccines
1056216 Pfizer Incorporated Chesterfield R&D Biologics & Proteins Preclinical - Phase 2A
1062193 Pfizer Incorporated Richland Animal Health
1056477 Pfizer Incorporated Rochester Parenteral CMO
1049213 Pfizer Incorporated Collegeville Proprietary R&D
1030108 Pfizer Incorporated Barceloneta Viagra Tablets and Other Capsules
1024952 Pfizer Incorporated Saint-Laurent OTC Tablets, Capsules, Topicals & Heatwraps
1018744 Pfizer Incorporated Andover Coagulation Factor IX, rhBMP & Polysaccharides
1015479 Pfizer Incorporated Groton Pharmaceutical R&D
1012993 Pfizer Incorporated Kalamazoo APIs, Sterile Injectables,
Capsules
1009905 Pfizer Incorporated Franklin Heparin
1018739 Pfizer Incorporated Cambridge (Will move to new plant 30335714)
1011658 Pfizer Incorporated Sanford Antibacteria Pediatric Vaccines Prevnar Injectables
3028081 Pfizer Incorporated Boston Center For Therapeutic Innovation
1513299 Pfizer Incorporated Peapack Pharmaceutical Antibiotics
1507220 Pfizer Incorporated Rouses Point Premarin Estrogen Tablets & Effexor XR Capsules
1078457 Pfizer Incorporated Pearl River Research and Development
1081781 Pfizer Incorporated Brandon Premarin APIs
1070637 Pfizer Incorporated Middleton Pain Medication
1030135 Pfizer Incorporated Guayama Shampoos, Lotions and other Healthcare Products
1031923 Pfizer SA de CV Toluca Pharmacueticals

Industrial Info Resources (IIR), with global headquarters in Sugar Land, Texas, three offices in North America and 10 international offices, is the leading provider of global market intelligence specializing in the industrial process, heavy manufacturing and energy markets. Industrial Info's quality-assurance philosophy, the Living Forward Reporting Principle™, provides up-to-the-minute intelligence on what's happening now, while constantly keeping track of future opportunities.
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